Computational model incorporating positive and negative feedback loops of proteins in Aplysia to study "the dynamics of kinase activity produced by different stimulus protocols and predict the critical roles of kinase interactions in the dynamics of these pathways."
Model Type: Molecular Network
Region(s) or Organism(s): Aplysia
Cell Type(s): Aplysia sensory neuron
Transmitters: Serotonin; Neurotrophin
Model Concept(s): Long-term Synaptic Plasticity
Simulation Environment: XPPAUT
References:
Zhang Y, Smolen PD, Cleary LJ, Byrne JH. (2021). Quantitative description of the interactions among kinase cascades underlying long-term plasticity of Aplysia sensory neurons Scientific reports. 11 [PubMed]