Interactions among kinase cascades underlying LTP in Aplysia sensory neurons (Zhang et al 2021)

Computational model incorporating positive and negative feedback loops of proteins in Aplysia to study "the dynamics of kinase activity produced by different stimulus protocols and predict the critical roles of kinase interactions in the dynamics of these pathways."

Model Type: Molecular Network

Region(s) or Organism(s): Aplysia

Cell Type(s): Aplysia sensory neuron

Transmitters: Serotonin; Neurotrophin

Model Concept(s): Long-term Synaptic Plasticity

Simulation Environment: XPPAUT


Zhang Y, Smolen PD, Cleary LJ, Byrne JH. (2021). Quantitative description of the interactions among kinase cascades underlying long-term plasticity of Aplysia sensory neurons Scientific reports. 11 [PubMed]

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