An ODE model of the inspiratory & sigh rhythms (Borrus et al., 2024)

Our work aims to understand the cellular and synaptic mechanisms underlying eupnea and sigh rhythms in the brain. Part of our work benefited from a mathematical model that made predictions about key components of both rhythm generators. We show a network a neurons can generate two oscillations simultaneously via different mechanisms.

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s):

Cell Type(s): PreBotzinger complex neuron





Model Concept(s): Brain Rhythms; Oscillations; Respiratory control

Simulation Environment: MATLAB; XPPAUT

Implementer(s): Borrus, Daniel


Borrus DS et al. (2024). Inspiratory and sigh breathing rhythms depend on distinct cellular signalling mechanisms in the preBötzinger complex. The Journal of physiology. [PubMed]

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