Our work aims to understand the cellular and synaptic mechanisms underlying eupnea and sigh rhythms in the brain. Part of our work benefited from a mathematical model that made predictions about key components of both rhythm generators. We show a network a neurons can generate two oscillations simultaneously via different mechanisms.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s):
Cell Type(s): PreBotzinger complex neuron
Currents:
Receptors:
Genes:
Transmitters:
Model Concept(s): Brain Rhythms; Oscillations; Respiratory control
Simulation Environment: MATLAB; XPPAUT
Implementer(s): Borrus, Daniel
References:
Borrus DS et al. (2024). Inspiratory and sigh breathing rhythms depend on distinct cellular signalling mechanisms in the preBötzinger complex. The Journal of physiology. [PubMed]