We modeled the locomotion CPG in neonatal mice, and our model produces both episodic and continuous locomotion, similar to activity seen in experimental recordings of motor neurons in the isolated spinal cords of neonatal mice. Our model is presented in Sharples SA, Parker J, Cruz JM, Vargas A, Lognon AP, Cheng N, Young L, Shonak A, Cymbalyuk G, Whelan PJ. Mechanisms of Episodic Rhythmicity Contributions of h-and Na+/K+ pump currents to the generation of episodic and continuous rhythmic activities. 2021. Frontiers in Cellular Neuroscience. 579. Accepted.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Spinal cord Ia interneuron
Currents: I Na, slow inactivation; Na/K pump; I K,leak; I Na, leak; I K; I h
Simulation Environment: C or C++ program
Implementer(s): Parker, Jessica; Varga, Alex; Cymbalyuk, Gennady
References:
Sharples SA et al. (2021). Mechanisms of Episodic Rhythmicity Contributions of h-and Na+/K+ pump currents to the generation of episodic and continuous rhythmic activities Frontiers in cellular neuroscience. 15 [PubMed]