Spreading Depolarization in Brain Slices (Kelley et al. 2022)

A tissue-scale model of spreading depolarization (SD) in brain slices. We used the NEURON simulator's reaction-diffusion framework to implement embed thousands of neurons (based on the the model from Wei et al. 2014) in the extracellular space of a brain slice, which is itself embedded in an bath solution. We initiate SD in the slice by elevating extracellular K+ in a spherical region at the center of the slice. Effects of hypoxia and propionate on the slice were modeled by appropriate changes to the volume fraction and tortuosity of the extracellular space and oxygen/chloride concentrations.

Model Type: Extracellular; Neuron or other electrically excitable cell; Glia

Currents: Na/K pump; NKCC1; KCC2; I Na, leak; I Cl, leak; I K,leak; I K; I Na,t

Model Concept(s): Spreading depolarization; Spreading depression; Reaction-diffusion

Simulation Environment: NEURON

Implementer(s): Kelley, Craig; Newton, Adam J H [adam.newton at yale.edu]; Lytton, William [bill.lytton at downstate.edu]; McDougal, Robert [robert.mcdougal at yale.edu]


Kelley C, Newton AJH, Hrabetova S, McDougal RA, Lytton WW. (2022). Multiscale Computer Modeling of Spreading Depolarization in Brain Slices eNeuro. 9 [PubMed]

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