Particle-Swarm Based Modelling Reveals Two Distinct Classes of CRH^{PVN} Neurons (Lameu et al 2022)

"... We developed a computational modelling platform that uses particle swarm optimization to rapidly and accurately fit biophysical neuron models to patched CRHPVN neurons. A model was fitted to each patched neuron without the use of dynamic clamping, or other procedures requiring sophisticated inputs and fitting algorithms. Any neuron undergoing standard current clamp step protocols for a few minutes can be fitted by this procedure..."

Region(s) or Organism(s): Mouse

Cell Type(s): Abstract integrate-and-fire adaptive exponential (AdEx) neuron; Hypothalamus PVN CRH neuron

Simulation Environment: MATLAB


Lameu EL et al. (2022). Particle-swarm based modelling reveals two distinct classes of CRH^PVN neurons J Physiol. [PubMed]

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