Hyperpolarization-activated inward current and dynamic range of electrical synapse (Stein et al '22)

Electrical synaptic transmission and voltage-gated ionic currents are often studied independently from one another. This model allows to study the interactions between the hyperpolarization-activated inward ionic current and a rectifying electrical synapse. Two single compartment nonspiking neurons are coupled through a rectifying electrical synapse. Current pulses are applied into the presynaptic neuron. The amplitude of the electrical postsynaptic potentials is measured. Ih can be added to either the pre- or postsynaptic neuron, or both. The cells represent the the MCN1 and LG neurons in the crab stomatogastric ganglion.

Model Type: Synapse; Neuron or other electrically excitable cell

Region(s) or Organism(s): Stomatogastric ganglion

Cell Type(s): Stomatogastric Ganglion (STG) Modulatory commissural neuron 1 (MCN1); Stomatogastric Ganglion (STG) Lateral Gastric (LG) cell; Hodgkin-Huxley neuron

Currents: I h

Model Concept(s): Invertebrate

Simulation Environment: Mathematica

Implementer(s): Harris, Allison L; Stein, Wolfgang [wstein@ilstu.edu]


Stein W et al. (2022). The dynamic range of voltage-dependent gap junction signaling is maintained by Ih-induced membrane potential depolarization Journal of neurophysiology. 127 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.