This model allows to simulate pacemaking activity in 37 fully reconstructed neurons. Calcium and sodium conductances vary by 11 increments in the Axon bearing dendrite part to simulate a 11*11*37 models. For each model Action potential (AP) properties are measured : frequency, amplitude, Threshold, Half duration, max first and second derivative. AP and conductances traces are then saved in a csv file.
Region(s) or Organism(s): Basal ganglia
Cell Type(s): Dopaminergic substantia nigra neuron
Simulation Environment: NEURON
Implementer(s): Tell, Fabien [fabien.tell at univ-amu.fr]
Moubarak E, Inglebert Y, Tell F, Goaillard J-M. (2022). Morphological determinants of cell-to-cell variations in action potential in substantia nigra dopaminergic neurons J Neurosci.