This model allows to simulate pacemaking activity in 37 fully reconstructed neurons. Calcium and sodium conductances vary by 11 increments in the Axon bearing dendrite part to simulate a 11*11*37 models. For each model Action potential (AP) properties are measured : frequency, amplitude, Threshold, Half duration, max first and second derivative. AP and conductances traces are then saved in a csv file.
Model Type: Axon; Dendrite; Neuron or other electrically excitable cell
Region(s) or Organism(s): Basal ganglia
Cell Type(s): Dopaminergic substantia nigra neuron
Currents: I Potassium; I Na,t; I Sodium; Ca pump; I A; I K,Ca; IK Skca; I h
Model Concept(s): Active Dendrites; Action Potential Initiation; Action Potentials; Dendritic Action Potentials
Simulation Environment: NEURON
Implementer(s): Tell, Fabien [fabien.tell at univ-amu.fr]
References:
Moubarak E, Inglebert Y, Tell F, Goaillard J-M. (2022). Morphological determinants of cell-to-cell variations in action potential in substantia nigra dopaminergic neurons J Neurosci.