Morphological determinants of action potential dynamics in substantia nigra (Moubarak et al 2022)

This model allows to simulate pacemaking activity in 37 fully reconstructed neurons. Calcium and sodium conductances vary by 11 increments in the Axon bearing dendrite part to simulate a 11*11*37 models. For each model Action potential (AP) properties are measured : frequency, amplitude, Threshold, Half duration, max first and second derivative. AP and conductances traces are then saved in a csv file.

Model Type: Axon; Dendrite; Neuron or other electrically excitable cell

Region(s) or Organism(s): Basal ganglia

Cell Type(s): Dopaminergic substantia nigra neuron

Currents: I Potassium; I Na,t; I Sodium; Ca pump; I A; I K,Ca; IK Skca; I h

Model Concept(s): Active Dendrites; Action Potential Initiation; Action Potentials; Dendritic Action Potentials

Simulation Environment: NEURON

Implementer(s): Tell, Fabien [fabien.tell at]


Moubarak E, Inglebert Y, Tell F, Goaillard J-M. (2022). Morphological determinants of cell-to-cell variations in action potential in substantia nigra dopaminergic neurons J Neurosci.

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