A sensorimotor-spinal cord model (Hoshino et al. 2022)

To elucidate how the flattening of sensory tuning due to a deficit in tonic inhibition slows motor responses, we simulated a neural network model in which a sensory cortical network (NS) and a motor cortical network (NM) are reciprocally connected, and the NM projects to spinal motoneurons (Mns). The NS was presented with a feature stimulus and the reaction time of Mns was measured. The flattening of sensory tuning in NS caused by decreasing the centration of GABA in extracellular space resulted in a decrease in the stimulus-sensitive NM pyramidal cell activity while increasing the stimulus-insensitive NM pyramidal cell activity, thereby prolonging the reaction time of Mns to the applied feature stimulus. We suggest that a reduction in extracellular GABA concentration in sensory cortex may interfere with selective activation in motor cortex, leading to slowing the activation of spinal motoneurons and therefore to slowing motor responses.

Model Type: Spiking neural network

Region(s) or Organism(s): Neocortex; Spinal motoneuron

Cell Type(s): Abstract integrate-and-fire leaky neuron

Receptors: AMPA; GabaA

Transmitters: Glutamate; Gaba

Model Concept(s): Action Potentials

Simulation Environment: C or C++ program


Hoshino O, Zheng M, Fukuoka Y. (2022). Effect of cortical extracellular GABA on motor response Journal of computational neuroscience. 50 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.