Biochemical Systems Theory Model of SARS-CoV-2 infection network (Sasidharakurup et al., 2021)

"We report here a mathematical model of SARS-CoV-2 infection pathway network with cytokine storm, oxidative stress, thrombosis, insulin resistance, and nitric oxide (NO) pathways. The biochemical systems theory model shows autocrine loops with positive feedback enabling excessive immune response, cytokines, transcription factors, and interferons, which can imbalance homeostasis of the system."

Model Type: Molecular Network

Model Concept(s): Signaling pathways; COVID-19

Simulation Environment: CellDesigner

Implementer(s): Sasidharakurup, Hemalatha [hemalathas at]; Diwakar, Shyam [shyam at]


Sasidharakurup H, Kumar G, Nair B, Diwakar S. (2021). Mathematical Modeling of Severe Acute Respiratory Syndrome Coronavirus 2 Infection Network with Cytokine Storm, Oxidative Stress, Thrombosis, Insulin Resistance, and Nitric Oxide Pathways OMICS. 25(12) [PubMed]

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