Spiny neuron model with dopamine-induced bistability (Gruber et al 2003)

These files implement a model of dopaminergic modulation of voltage-gated currents (called kir2 and caL in the original paper). See spinycell.html for details of usage and implementation. For questions about this implementation, contact Ted Carnevale (ted.carnevale@yale.edu)

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Neostriatum medium spiny direct pathway GABA cell

Currents: I K,leak; I h; I A, slow

Receptors: D1; Dopaminergic Receptor

Genes: Cav1.3 CACNA1D; D1 DRD1A

Transmitters: Dopamine

Model Concept(s): Intrinsic plasticity

Simulation Environment: NEURON

Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu]


Gruber AJ, Solla SA, Surmeier DJ, Houk JC. (2003). Modulation of striatal single units by expected reward: a spiny neuron model displaying dopamine-induced bistability. Journal of neurophysiology. 90 [PubMed]

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