These files implement a model of dopaminergic modulation of voltage-gated currents (called kir2 and caL in the original paper). See spinycell.html for details of usage and implementation. For questions about this implementation, contact Ted Carnevale (ted.carnevale@yale.edu)
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell
Currents: I K,leak; I h; I A, slow
Receptors: D1; Dopaminergic Receptor
Genes: Cav1.3 CACNA1D; D1 DRD1A
Transmitters: Dopamine
Model Concept(s): Intrinsic plasticity
Simulation Environment: NEURON
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu]
References:
Gruber AJ, Solla SA, Surmeier DJ, Houk JC. (2003). Modulation of striatal single units by expected reward: a spiny neuron model displaying dopamine-induced bistability. Journal of neurophysiology. 90 [PubMed]