Olfactory bulb mitral cell: synchronization by gap junctions (Migliore et al 2005)

In a realistic model of two electrically connected mitral cells, the paper shows that the somatically-measured experimental properties of Gap Junctions (GJs) may correspond to a variety of different local coupling strengths and dendritic distributions of GJs in the tuft. The model suggests that the propagation of the GJ-induced local tuft depolarization is a major mechanim for intraglomerular synchronization of mitral cells.

Model Type: Realistic Network

Region(s) or Organism(s): Olfactory bulb

Cell Type(s): Olfactory bulb main mitral GLU cell

Currents: I Na,t; I A; I K

Model Concept(s): Dendritic Action Potentials; Synchronization; Active Dendrites; Influence of Dendritic Geometry; Olfaction

Simulation Environment: NEURON

Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu]

References:

Migliore M, Hines ML, Shepherd GM. (2005). The role of distal dendritic gap junctions in synchronization of mitral cell axonal output. Journal of computational neuroscience. 18 [PubMed]