S cell network (Moss et al 2005)

Excerpts from the abstract: S cells form a chain of electrically coupled neurons that extends the length of the leech CNS and plays a critical role in sensitization during whole-body shortening. ... Serotonin ... increasedAP latency across the electrical synapse, suggesting that serotonin reduced coupling between S cells. ... Serotonin modulated instantaneous AP frequency when APs were initiated in separate S cells and in a computational model of S cell activity following mechanosensory input. Thus, serotonergic modulation of S cell electrical synapses may contribute to changes in the pattern of activity in the S cell network. See paper for more.

Model Type: Realistic Network

Region(s) or Organism(s): Leech

Cell Type(s): Leech S cell

Currents: I Sodium; I Potassium

Model Concept(s): Activity Patterns; Invertebrate

Simulation Environment: SNNAP

Implementer(s): Baxter, Douglas; Moss, Brenda [bmoss at usd.edu]; Byrne, John [john.h.byrne at uth.tmc.edu]


Moss BL, Fuller AD, Sahley CL, Burrell BD. (2005). Serotonin modulates axo-axonal coupling between neurons critical for learning in the leech. Journal of neurophysiology. 94 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.