IA and IT interact to set first spike latency (Molineux et al 2005)

Using patch clamp and modeling, we illustrate that spike latency characteristics are the product of an interplay between I(A) and low-threshold calcium current (I(T)) that requires a steady-state difference in the inactivation parameters of the currents. Furthermore, we show that the unique first-spike latency characteristics of stellate cells have important implications for the integration of coincident IPSPs and EPSPs, such that inhibition can shift first-spike latency to differentially modulate the probability of firing.

Model Type: Neuron or other electrically excitable cell

Currents: I Na,t; I T low threshold; I A; I K

Model Concept(s): Action Potential Initiation; Coincidence Detection

Simulation Environment: MATLAB

Implementer(s): Fernandez FR [ffernand at ucalgary.ca]; Mehaffey WH


Molineux ML, Fernandez FR, Mehaffey WH, Turner RW. (2005). A-type and T-type currents interact to produce a novel spike latency-voltage relationship in cerebellar stellate cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]

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