Cortical fast-spiking (FS) interneurons display highly variable electrophysiological properties. We hypothesize that this variability emerges naturally if one assumes a continuous distribution of properties in a small set of active channels. We construct a minimal, single-compartment conductance-based model of FS cells that includes transient Na+, delayed-rectifier K+, and slowly inactivating d-type K+ conductances. The model may display delay to firing. Stuttering (elliptic bursting) and subthreshold oscillations may be observed for small Na+ window current.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Neocortex fast spiking (FS) interneuron
Currents: I Na,t; I K; I A, slow; I_KD
Model Concept(s): Bursting; Action Potentials; Stuttering; Delay
Simulation Environment: NEURON; XPPAUT
Golomb D et al. (2007). Mechanisms of firing patterns in fast-spiking cortical interneurons. PLoS computational biology. 3 [PubMed]