Thomas EA, Reid CA, Berkovic SF, Petrou S. (2009). Prediction by modeling that epilepsy may be caused by very small functional changes in ion channels. Archives of neurology. 66 [PubMed]

See more from authors: Thomas EA · Reid CA · Berkovic SF · Petrou S

References and models cited by this paper

Babb TL, Kupfer WR, Pretorius JK, Crandall PH, Levesque MF. (1991). Synaptic reorganization by mossy fibers in human epileptic fascia dentata. Neuroscience. 42 [PubMed]

Berkovic SF, Mulley JC, Scheffer IE, Petrou S. (2006). Human epilepsies: interaction of genetic and acquired factors. Trends in neurosciences. 29 [PubMed]

Bowser DN et al. (2002). Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy. Proceedings of the National Academy of Sciences of the United States of America. 99 [PubMed]

Dudek FE, Sutula TP. (2007). Epileptogenesis in the dentate gyrus: a critical perspective. Progress in brain research. 163 [PubMed]

Dyhrfjeld-Johnsen J et al. (2007). Topological determinants of epileptogenesis in large-scale structural and functional models of the dentate gyrus derived from experimental data. Journal of neurophysiology. 97 [PubMed]

Helbig I et al. (2009). 15q13.3 microdeletions increase risk of idiopathic generalized epilepsy. Nature genetics. 41 [PubMed]

Helbig I, Scheffer IE, Mulley JC, Berkovic SF. (2008). Navigating the channels and beyond: unravelling the genetics of the epilepsies. The Lancet. Neurology. 7 [PubMed]

Heron SE et al. (2007). Extended spectrum of idiopathic generalized epilepsies associated with CACNA1H functional variants. Annals of neurology. 62 [PubMed]

Houser CR et al. (1990). Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. 10 [PubMed]

Lytton WW. (2008). Computer modelling of epilepsy. Nature reviews. Neuroscience. 9 [PubMed]

McCarthy MI et al. (2008). Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nature reviews. Genetics. 9 [PubMed]

Meadows LS et al. (2002). Functional and biochemical analysis of a sodium channel beta1 subunit mutation responsible for generalized epilepsy with febrile seizures plus type 1. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]

Morgan RJ, Soltesz I. (2008). Nonrandom connectivity of the epileptic dentate gyrus predicts a major role for neuronal hubs in seizures. Proceedings of the National Academy of Sciences of the United States of America. 105 [PubMed]

Noebels JL. (2003). The biology of epilepsy genes. Annual review of neuroscience. 26 [PubMed]

Ogiwara I et al. (2007). Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Reid CA, Berkovic SF, Petrou S. (2009). Mechanisms of human inherited epilepsies. Progress in neurobiology. 87 [PubMed]

Santhakumar V, Aradi I, Soltesz I. (2005). Role of mossy fiber sprouting and mossy cell loss in hyperexcitability: a network model of the dentate gyrus incorporating cell types and axonal topography. Journal of neurophysiology. 93 [PubMed]

Santhakumar V, Ratzliff AD, Jeng J, Toth Z, Soltesz I. (2001). Long-term hyperexcitability in the hippocampus after experimental head trauma. Annals of neurology. 50 [PubMed]

Staley KJ, Otis TS, Mody I. (1992). Membrane properties of dentate gyrus granule cells: comparison of sharp microelectrode and whole-cell recordings. Journal of neurophysiology. 67 [PubMed]

Sutula TP, Dudek FE. (2007). Unmasking recurrent excitation generated by mossy fiber sprouting in the epileptic dentate gyrus: an emergent property of a complex system. Progress in brain research. 163 [PubMed]

Sutula TP, Hermann B. (1999). Progression in mesial temporal lobe epilepsy. Annals of neurology. 45 [PubMed]

Tan HO et al. (2007). Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy. Proceedings of the National Academy of Sciences of the United States of America. 104 [PubMed]

Tang B, Sander T, Craven KB, Hempelmann A, Escayg A. (2008). Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy. Neurobiology of disease. 29 [PubMed]

Thomas EA, Petrou S. (2008). Case for realistic modeling in understanding seizures. Expert review of neurotherapeutics. 8 [PubMed]

Thomas EA, Reid CA, Petrou S. (2010). Mossy fiber sprouting interacts with sodium channel mutations to increase dentate gyrus excitability. Epilepsia. 51 [PubMed]

Thomas EA, Xu R, Petrou S. (2007). Computational analysis of the R85C and R85H epilepsy mutations in Na+ channel beta1 subunits. Neuroscience. 147 [PubMed]

Xu R et al. (2007). Generalized epilepsy with febrile seizures plus-associated sodium channel beta1 subunit mutations severely reduce beta subunit-mediated modulation of sodium channel function. Neuroscience. 148 [PubMed]

Xu R et al. (2007). A childhood epilepsy mutation reveals a role for developmentally regulated splicing of a sodium channel. Molecular and cellular neurosciences. 35 [PubMed]

Yu FH et al. (2006). Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy. Nature neuroscience. 9 [PubMed]

de Lanerolle NC, Kim JH, Robbins RJ, Spencer DD. (1989). Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy. Brain research. 495 [PubMed]

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