This model was implemented by Rob Morgan in the Soltesz lab at UC Irvine. It is a scaleable model of the rat dentate gyrus including four cell types. This model runs in serial (on a single processor) and has been published at the size of 50,000 granule cells (with proportional numbers of the other cells).
Model Type: Realistic Network
Region(s) or Organism(s): Dentate gyrus
Cell Type(s): Dentate gyrus granule GLU cell; Dentate gyrus mossy cell; Dentate gyrus basket cell; Dentate gyrus hilar cell
Model Concept(s): Epilepsy
Simulation Environment: NEURON
Implementer(s): Bezaire, Marianne [mariannejcase at gmail.com]; Morgan, Robert [polomav at gmail.com]
References:
Santhakumar V, Aradi I, Soltesz I. (2005). Role of mossy fiber sprouting and mossy cell loss in hyperexcitability: a network model of the dentate gyrus incorporating cell types and axonal topography. Journal of neurophysiology. 93 [PubMed]
Dyhrfjeld-Johnsen J et al. (2007). Topological determinants of epileptogenesis in large-scale structural and functional models of the dentate gyrus derived from experimental data. Journal of neurophysiology. 97 [PubMed]
Morgan RJ, Soltesz I. (2008). Nonrandom connectivity of the epileptic dentate gyrus predicts a major role for neuronal hubs in seizures. Proceedings of the National Academy of Sciences of the United States of America. 105 [PubMed]
Morgan RJ, Santhakumar V, Soltesz I. (2007). Modeling the dentate gyrus. Progress in brain research. 163 [PubMed]