Medial reticular formation of the brainstem: anatomy and dynamics (Humphries et al. 2006, 2007)


A set of models to study the medial reticular formation (mRF) of the brainstem. We developed a collection of algorithms to derive the adult-state wiring of the model: one set a stochastic model; the other set mimicking the developmental process. We found that the anatomical models had small-world properties, irrespective of the choice of algorithm; and that the cluster-like organisation of the mRF may have arisen to minimise wiring costs. (The model code includes options to be run as dynamic models; papers examining these dynamics are included in the .zip file).

Model Type: Realistic Network

Model Concept(s): Activity Patterns; Action Selection/Decision Making; Connectivity matrix; Development; Sensory processing

Simulation Environment: MATLAB

Implementer(s): Humphries, Mark D [m.d.humphries at shef.ac.uk]

References:

Humphries MD, Gurney K, Prescott TJ. (2006). The brainstem reticular formation is a small-world, not scale-free, network. Proceedings. Biological sciences 273 [PubMed]

Humphries MD, Gurney K, Prescott TJ. (2007). Is there a brainstem substrate for action selection? Philosophical transactions of the Royal Society of London. Series B, Biological sciences 362 [PubMed]