"Coordination of neocortical oscillations has been hypothesized to underlie the "binding" essential to cognitive function. However, the mechanisms that generate neocortical oscillations in physiological frequency bands remain unknown. We hypothesized that interlaminar relations in neocortex would provide multiple intermediate loops that would play particular roles in generating oscillations, adding different dynamics to the network. We simulated networks from sensory neocortex using 9 columns of event-driven rule-based neurons wired according to anatomical data and driven with random white-noise synaptic inputs. ..."
Model Type: Realistic Network
Region(s) or Organism(s): Neocortex
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; Neocortex V1 interneuron basket PV GABA cell; Neocortex fast spiking (FS) interneuron; Neocortex spiny stellate cell
Receptors: GabaA; AMPA; NMDA; Gaba
Model Concept(s): Activity Patterns; Oscillations; Synchronization; Laminar Connectivity
Simulation Environment: NEURON
Implementer(s): Lytton, William [bill.lytton at downstate.edu]; Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org]
References:
Neymotin SA, Lee H, Park E, Fenton AA, Lytton WW. (2011). Emergence of physiological oscillation frequencies in a computer model of neocortex. Frontiers in computational neuroscience. 5 [PubMed]