Compartmental model of a layer 2/3 pyramidal cell in the rat somatosensory cortex, exploring NMDA-dependent sensitivity to the temporal sequence of synaptic activation.
Model Type: Neuron or other electrically excitable cell; Dendrite
Region(s) or Organism(s): Neocortex
Cell Type(s): Neocortex L2/3 pyramidal GLU cell
Receptors: NMDA
Transmitters: Glutamate
Model Concept(s): Spatio-temporal Activity Patterns; Synaptic Integration; Direction Selectivity
Simulation Environment: NEURON
References:
Branco T, Clark BA, Häusser M. (2010). Dendritic discrimination of temporal input sequences in cortical neurons. Science (New York, N.Y.) 329 [PubMed]
Branco T, Häusser M. (2011). Synaptic integration gradients in single cortical pyramidal cell dendrites. Neuron 69 [PubMed]