This model produces the hippocampal CA3 neural network model used in the paper below. It has two modes of operation, a default mode and a circadian mode. In the circadian mode, parameters are swept through a range of values. This model can be quite easily adapted to produce theta and gamma oscillations, as certain parameter sweeps will reveal (see Figures). BASH scripts interact with GENESIS 2.3 to implement parameter sweeps. The model contains four cell types derived from prior papers. CA3 pyramidal are derived from Traub et al (1991); Basket, stratum oriens (O-LM), and Medial Septal GABAergic (MSG) interneurons are taken from Hajos et al (2004).
Model Type: Realistic Network; Neuron or other electrically excitable cell
Region(s) or Organism(s): Hippocampus; Medial Septum
Cell Type(s): Hippocampus CA3 pyramidal GLU cell; Hippocampus CA3 interneuron basket GABA cell; Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron; Hippocampus septum medial GABAergic neuron
Currents: I Na,t; I A; I K; I h; I K,Ca; I Calcium
Model Concept(s): Epilepsy; Brain Rhythms; Circadian Rhythms
Simulation Environment: GENESIS; MATLAB
Implementer(s): Stanley, David A
References:
Stanley DA et al. (2013). Phase shift in the 24-hour rhythm of hippocampal EEG spiking activity in a rat model of temporal lobe epilepsy. Journal of neurophysiology. 110 [PubMed]