"1. A large-scale computer model of the piriform cortex was constructed on the basis of the known anatomic and physiological organization of this region. 2. The oscillatory field potential and electroencephalographic (EEG) activity generated by the model was compared with actual physiological results. The model was able to produce patterns of activity similar to those recorded physiologically in response to both weak and strong electrical shocks to the afferent input. The model also generated activity patterns similar to EEGs recorded in behaving animals. 3. ..."
Model Type: Realistic Network
Region(s) or Organism(s): Olfactory cortex
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; Neocortex fast spiking (FS) interneuron
Currents: I Chloride; I Na,t; I K
Model Concept(s): Oscillations; Extracellular Fields; Evoked LFP; Olfaction
Simulation Environment: GENESIS (web link to model)
References:
Wilson M, Bower JM. (1992). Cortical oscillations and temporal interactions in a computer simulation of piriform cortex. Journal of neurophysiology. 67 [PubMed]
Bower JM, Beeman D. (2003). The book of GENESIS exploring realistic neural models with the GEneral NEural SImulation System (2nd ed).