This is an adaptation of Poirazi et al.'s (2003) CA1 model that is used to measure BAP-induced voltage and calcium signals in spines after simulated Schaffer collateral synapse stimulation. In the model, the peak calcium concentration is highly correlated with soma-synapse distance under a number of physiologically-realistic suprathreshold stimulation regimes and for a range of dendritic morphologies. There are also simulations demonstrating that peak calcium can be used to set up a synaptic democracy in a homeostatic manner, whereby synapses regulate their synaptic strength on the basis of the difference between peak calcium and a uniform target value.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Currents: I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I Mixed; I R; I_AHP
Model Concept(s): Dendritic Action Potentials; Synaptic Plasticity
Simulation Environment: NEURON
Implementer(s): Sterratt, David ; Groen, Martine R [martine.groen at gmail.com]
References:
Sterratt DC, Groen MR, Meredith RM, van Ooyen A. (2012). Spine calcium transients induced by synaptically-evoked action potentials can predict synapse location and establish synaptic democracy. PLoS computational biology 8 [PubMed]