The Inferior Olive is a brain structure in which neurons are solely connected to each other through gap-junctions. Its behavior is characterized by spontaneous subthreshold oscillation, frequency changes in the subthreshold oscillation, stable phase differences between neurons, and propagating waves of activity. Our model based on actual IO topology can reproduce these behaviors and provides a mechanistic explanation thereof.
Model Type: Realistic Network
Cell Type(s): Inferior olive neuron
Currents: I T low threshold
Transmitters: Gaba
Model Concept(s): Oscillations
Simulation Environment: NEURON
Implementer(s): Torben-Nielsen, Ben [btorbennielsen at gmail.com]
References:
Torben-Nielsen B, Segev I, Yarom Y. (2012). The generation of phase differences and frequency changes in a network model of inferior olive subthreshold oscillations. PLoS computational biology. 8 [PubMed]