“… Here we present experimental and computational evidence of the interplay among hippocampal synaptic circuitry, neuronal morphology, external electric fields, and network activity. Electrophysiological data are used to constrain and validate an anatomically and biophysically realistic model of area CA1 containing pyramidal cells and two interneuron types: dendritic- and perisomatic-targeting. We report two lines of results: addressing the network structure capable of generating theta-modulated gamma rhythms, and demonstrating electric field effects on those rhythms. First, theta-modulated gamma rhythms require specific inhibitory connectivity. … The second major finding is that subthreshold electric fields robustly alter the balance between different rhythms. …”
Model Type: Realistic Network; Extracellular
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Model Concept(s): Brain Rhythms
Simulation Environment: NEURON
References:
Berzhanskaya J, Chernyy N, Gluckman BJ, Schiff SJ, Ascoli GA. (2013). Modulation of hippocampal rhythms by subthreshold electric fields and network topology. Journal of computational neuroscience. 34 [PubMed]