"… To understand the biochemical mechanisms of this timekeeping, we have developed a detailed mathematical model of the mammalian circadian clock. Our model can accurately predict diverse experimental data including the phenotypes of mutations or knockdown of clock genes as well as the time courses and relative expression of clock transcripts and proteins. Using this model, we show how a universal motif of circadian timekeeping, where repressors tightly bind activators rather than directly binding to DNA, can generate oscillations when activators and repressors are in stoichiometric balance. …"
Model Type: Molecular Network
Cell Type(s): Suprachiasmatic nucleus (SCN) neuron
Model Concept(s): Oscillations; Brain Rhythms; Circadian Rhythms
Simulation Environment: XPPAUT; MATLAB; Mathematica
Implementer(s): Kim, Jae Kyoung [kimjack0 at kaist.ac.kr]
Kim JK, Forger DB. (2012). A mechanism for robust circadian timekeeping via stoichiometric balance. Molecular systems biology 8 [PubMed]