A generic three-tier MAPK cascade model constructed by comparing previous MAPK models covering a range of biosystems. Pseudo parameters and random sampling were employed for qualitative analysis. A range of kinetic behaviors of MAPK activation, including ultrasensitivity, bistability, transient activation and oscillation, were successfully reproduced in this generic model. The mechanisms were revealed by statistic analysis of the parameter sets.
Model Type: Molecular Network
Model Concept(s): Methods
Simulation Environment: MATLAB
References:
Mai Z, Liu H. (2013). Random parameter sampling of a generic three-tier MAPK cascade model reveals major factors affecting its versatile dynamics PloS one. 8 [PubMed]