Dendritic signals command firing dynamics in a Cerebellar Purkinje Cell model (Genet et al. 2010)

This model endows the dendrites of a reconstructed Purkinje cells (PC) with the mechanism of Ca-dependent plateau potentials and spikes described in Genet, S., and B. Delord. 2002. A biophysical model of nonlinear dynamics underlying plateau potentials and calcium spikes in Purkinje cell dendrites. J. Neurophysiol. 88:2430–2444). It is a part of a comprehensive mathematical study suggesting that active electric signals in the dendrites of PC command epochs of firing and silencing of the PC soma.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Cerebellum Purkinje GABA cell

Currents: I K; I Ca,p; Ca pump

Transmitters: Gaba; Glutamate

Model Concept(s): Dendritic Action Potentials; Simplified Models; Active Dendrites; Detailed Neuronal Models; Action Potentials; Calcium dynamics; Conductance distributions

Simulation Environment: NEURON

Implementer(s): Genet, Stéphane [stephane.genet@upmc.fr]

References:

Genet S, Sabarly L, Guigon E, Berry H, Delord B. (2010). Dendritic signals command firing dynamics in a mathematical model of cerebellar Purkinje cells. Biophysical journal. 99 [PubMed]