Impact of dendritic atrophy on intrinsic and synaptic excitability (Narayanan & Chattarji, 2010)


These simulations examined the atrophy induced changes in electrophysiological properties of CA3 pyramidal neurons. We found these neurons change from bursting to regular spiking as atrophy increases. Region-specific atrophy induced region-specific increases in synaptic excitability in a passive dendritic tree. All dendritic compartments of an atrophied neuron had greater synaptic excitability and a larger voltage transfer to the soma than the control neuron.

Model Type: Neuron or other electrically excitable cell; Synapse; Dendrite

Region(s) or Organism(s): Hippocampus

Cell Type(s): Hippocampus CA3 pyramidal GLU cell

Currents: I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium; I_AHP

Receptors: AMPA

Transmitters: Glutamate

Model Concept(s): Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials; Conductance distributions

Simulation Environment: NEURON

Implementer(s): Narayanan, Rishikesh [rishi at iisc.ac.in]

References:

Narayanan R, Chattarji S. (2010). Computational analysis of the impact of chronic stress on intrinsic and synaptic excitability in the hippocampus. Journal of neurophysiology 103 [PubMed]