These simulations examined the atrophy induced changes in electrophysiological properties of CA3 pyramidal neurons. We found these neurons change from bursting to regular spiking as atrophy increases. Region-specific atrophy induced region-specific increases in synaptic excitability in a passive dendritic tree. All dendritic compartments of an atrophied neuron had greater synaptic excitability and a larger voltage transfer to the soma than the control neuron.
Model Type: Neuron or other electrically excitable cell; Synapse; Dendrite
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA3 pyramidal GLU cell
Currents: I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium; I_AHP
Receptors: AMPA
Transmitters: Glutamate
Model Concept(s): Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials; Conductance distributions
Simulation Environment: NEURON
Implementer(s): Narayanan, Rishikesh [rishi at iisc.ac.in]
References:
Narayanan R, Chattarji S. (2010). Computational analysis of the impact of chronic stress on intrinsic and synaptic excitability in the hippocampus. Journal of neurophysiology. 103 [PubMed]