Preserving axosomatic spiking features despite diverse dendritic morphology (Hay et al., 2013)

The authors found that linearly scaling the ion channel conductance densities of a reference model with the conductance load in 28 3D reconstructed layer 5 thick-tufted pyramidal cells was necessary to match the experimental statistics of these cells electrical firing properties.

Model Type: Neuron or other electrically excitable cell; Axon; Channel/Receptor; Dendrite

Region(s) or Organism(s): Neocortex

Cell Type(s): Neocortex L5/6 pyramidal GLU cell

Currents: I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I h; I K,Ca; I Calcium; I A, slow

Model Concept(s): Parameter Fitting; Action Potentials; Parameter sensitivity

Simulation Environment: NEURON

Implementer(s): Hay, Etay [etay.hay at mail.huji.ac.il]

References:

Hay E, Schürmann F, Markram H, Segev I. (2013). Preserving axosomatic spiking features despite diverse dendritic morphology. Journal of neurophysiology. 109 [PubMed]