Synaptic gating at axonal branches, and sharp-wave ripples with replay (Vladimirov et al. 2013)

The computational model of in vivo sharp-wave ripples with place cell replay. Excitatory post-synaptic potentials at dendrites gate antidromic spikes arriving from the axonal collateral, and thus determine when the soma and the main axon fire. The model allows synchronous replay of pyramidal cells during sharp-wave ripple event, and the replay is possible in both forward and reverse directions.

Model Type: Neuron or other electrically excitable cell; Axon; Dendrite; Connectionist Network

Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA1 basket cell

Currents: I Na,t; I A; I K; I K,leak; I K,Ca; I Calcium; I Potassium; I_AHP

Receptors: GabaA; AMPA

Transmitters: Gaba; Glutamate

Model Concept(s): Action Potential Initiation; Oscillations; Synchronization; Axonal Action Potentials; Place cell/field; Conduction failure; Brain Rhythms

Simulation Environment: NEURON

Implementer(s): Vladimirov, Nikita

References:

Vladimirov N, Tu Y, Traub RD. (2013). Synaptic gating at axonal branches, and sharp-wave ripples with replay: a simulation study. The European journal of neuroscience. 38 [PubMed]