The codes are directly related with the results presented in the manuscript; in brief, it is a computational investigation on the effects of optogenetic actuation on excitatory and inhibitory neurons when 3- and 4- state model is used to implement the ChR2 kinetics. Different parameters of optostimulation are investigated and the results compared with experimental data previously published by other research groups.
Model Type: Neuron or other electrically excitable cell; Channel/Receptor
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA1 interneuron oriens alveus GABA cell
Simulation Environment: MATLAB
Implementer(s): Stefanescu, Roxana [roxanast75 at gmail.com]
References:
Stefanescu RA, Shivakeshavan RG, Khargonekar PP, Talathi SS. (2013). Computational modeling of channelrhodopsin-2 photocurrent characteristics in relation to neural signaling. Bulletin of mathematical biology 75 [PubMed]