A mathematical model of the membrane action potential of the mammalian ventricular cell introduced in Luo, Rudy 1991 and used in Wang et al 2006 is made available here in XPP. The model is based, whenever possible, on recent single-cell and single-channel data and incorporates the possibility of changing extracellular potassium concentration [K]o. ... The results are consistent with recent experimental observations, and the model simulations relate these phenomena to the underlying ionic channel kinetics. See papers for more and details.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Cardiac ventricular cell
Currents: I Sodium; I Calcium; I Potassium; ATP-senstive potassium current; I_HERG; Na/Ca exchanger; I_Na,Ca; I_SERCA; KCNQ1; I_Ks; Ca pump
Model Concept(s): Action Potentials; Calcium dynamics; Triggered activity
Simulation Environment: XPPAUT
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]
References:
Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation. Circulation research. 74 [PubMed]
Wang YJ, Sung RJ, Lin MW, Wu SN. (2006). Contribution of BK(Ca)-channel activity in human cardiac fibroblasts to electrical coupling of cardiomyocytes-fibroblasts. The Journal of membrane biology. 213 [PubMed]