"... We propose a model in which synaptic strength is the product of a synapse-specific Hebbian factor and a postsynaptic- cell-specific homeostatic factor, with each factor separately arriving at a stable inactive state. This model captures ODP dynamics and has plausible biophysical substrates. We confirm model predictions experimentally that plasticity is inactive at stable states and that synaptic strength overshoots during recovery from visual deprivation. ..."
Model Type: Realistic Network
Cell Type(s): Neocortex L2/3 pyramidal GLU cell
Model Concept(s): Development; Homeostasis; Hebbian plasticity
Simulation Environment: MATLAB
References:
Toyoizumi T, Kaneko M, Stryker MP, Miller KD. (2014). Modeling the dynamic interaction of Hebbian and homeostatic plasticity. Neuron. 84 [PubMed]