TRPM8-dependent dynamic response in cold thermoreceptors (Olivares et al. 2015)

This model reproduces the dynamic response of cold thermoreceptors, transiently changing the firing rate upon heating or cooling. It also displays the 'static' or adapted firing patterns observed in these receptors.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Dorsal Root Ganglion (DRG) cell; Dorsal Root Ganglion cell: cold sensing

Currents: I Na,p; I Na,t; I K; I K,Ca; I trp; I TRPM8

Model Concept(s): Bursting; Temporal Pattern Generation; Oscillations; Homeostasis; Temperature; Sensory coding

Simulation Environment: NEURON; Python

Implementer(s): Orio, Patricio [patricio.orio at uv.cl]

References:

Olivares E et al. (2015). TRPM8-Dependent Dynamic Response in a Mathematical Model of Cold Thermoreceptor. PloS one. 10 [PubMed]