" ...Here we present a qualitative analysis of a recent mathematical model of astrocyte calcium responses. We show how the major response types are generated in the model as a result of the underlying bifurcation structure. By varying key channel parameters, mimicking blockers used by experimentalists, we manipulate this underlying bifurcation structure and predict how the distributions of responses can change. We find that store-operated calcium channels, plasma membrane bound channels with little activity during calcium transients, have a surprisingly strong effect, underscoring the importance of considering these channels in both experiments and mathematical settings. ..."
Model Type: Glia
Currents: Ca pump; I_SERCA; I Calcium
Receptors: IP3
Model Concept(s): Calcium dynamics; Oscillations; Bifurcation
Simulation Environment: MATLAB; XPPAUT
Implementer(s): Handy, Gregory [handy at math.utah.edu]; Taheri, Marsa
References:
Handy G, Taheri M, White JA, Borisyuk A. (2017). Mathematical investigation of IP3-dependent calcium dynamics in astrocytes. Journal of computational neuroscience. 42 [PubMed]