Muscle spindle feedback circuit (Moraud et al, 2016)

Here, we developed a computational model of the muscle spindle feedback circuits of the rat ankle that predicts the interactions between Epidural Stimulation and spinal circuit dynamics during gait.

Model Type: Realistic Network

Region(s) or Organism(s): Spinal motoneuron

Cell Type(s): Spinal cord motor neuron slow twitch

Currents: I K; I K,Ca; I Na,p; I Sodium

Model Concept(s): Sensory processing; Neuromodulation

Simulation Environment: NEURON; Python

Implementer(s): Capogrosso, Marco ; Formento, Emanuele

References:

Moraud EM et al. (2016). Mechanisms Underlying the Neuromodulation of Spinal Circuits for Correcting Gait and Balance Deficits after Spinal Cord Injury. Neuron. 89 [PubMed]