Activity dependent regulation of pacemaker channels by cAMP (Wang et al 2002)

Demonstration of the physiological consequences of the cyclic allosteric gating scheme for Ih mediated by HCN2 in thalamocortical relay cells.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell

Currents: I K,leak; I h

Genes: HCN2

Model Concept(s): Activity Patterns; Ion Channel Kinetics

Simulation Environment: NEURON

Implementer(s): Nolan, Matt [mfnolan at fido.cpmc.columbia.edu]; Chen, Shan [sc448 at columbia.edu]

References:

Wang J, Chen S, Nolan MF, Siegelbaum SA. (2002). Activity-dependent regulation of HCN pacemaker channels by cyclic AMP: signaling through dynamic allosteric coupling. Neuron. 36 [PubMed]