These NEURON simulations show the effect of prolonged inactivation of sodium channels on attenuation of trains of backpropagating action potentials (bAPs). The new sodium channel model is a Markov model derived using a state-mutating genetic algorithm, as described in the paper.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Currents: I A; I K; I Sodium; I Na, slow inactivation
Model Concept(s): Action Potentials; Ion Channel Kinetics; Markov-type model
Simulation Environment: NEURON
Implementer(s): Menon, Vilas [vilasmenon2008 at u dot northwestern dot edu]
References:
Menon V, Spruston N, Kath WL. (2009). A state-mutating genetic algorithm to design ion-channel models. Proceedings of the National Academy of Sciences of the United States of America. 106 [PubMed]