Interneuron Specific 3 Interneuron Model (Guet-McCreight et al, 2016)

In this paper we develop morphologically detailed multi-compartment models of Hippocampal CA1 interneuron specific 3 interneurons using cell current-clamp recordings and dendritic calcium imaging data. In doing so, we developed several variant models, as outlined in the associated README.html file.

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Hippocampus

Currents: I Na,t; I Na,p; I A

Genes: Kv3.1 KCNC1; Kv2.1 KCNB1

Model Concept(s): Action Potentials; Active Dendrites; Activity Patterns; Depolarization block; Detailed Neuronal Models; Ion Channel Kinetics

Simulation Environment: NEURON

Implementer(s): Guet-McCreight, Alexandre [alexandre.guet.mccreight at mail.utoronto.ca]

References:

Guet-McCreight A, Camiré O, Topolnik L, Skinner FK. (2016). Using a Semi-Automated Strategy to Develop Multi-Compartment Models That Predict Biophysical Properties of Interneuron-Specific 3 (IS3) Cells in Hippocampus. eNeuro. 3 [PubMed]