We tested the reproducibility and comparability of four astrocyte models (Manninen, Havela, Linne, 2017). Model by Riera et al. (2011) was one of them. We implemented and ran the model by Riera et al. (2011) using Jupyter Notebook. Model codes produce results of Figures 1 and 2 in Manninen, Havela, Linne (2017).
Model Type: Glia
Region(s) or Organism(s): Hippocampus
Cell Type(s): Astrocyte
Receptors: IP3
Model Concept(s): Calcium dynamics; Oscillations; Signaling pathways
Simulation Environment: Python
Implementer(s): Manninen, Tiina [tiina.h.manninen at gmail.com]
References:
Manninen T, Havela R, Linne M-L. (2017). Reproducibility and comparability of computational models for astrocyte calcium excitability Front. Neuroinform..
Riera J, Hatanaka R, Ozaki T, Kawashima R. (2011). Modeling the spontaneous Ca2+ oscillations in astrocytes: Inconsistencies and usefulness. Journal of integrative neuroscience. 10 [PubMed]
Riera J, Hatanaka R, Uchida T, Ozaki T, Kawashima R. (2011). Quantifying the uncertainty of spontaneous Ca2+ oscillations in astrocytes: particulars of Alzheimer's disease. Biophysical journal. 101 [PubMed]