"Transcranial magneto-acoustical stimulation (TMAS) uses ultrasonic waves and a static magnetic field to generate electric current in nerve tissues for the purpose of modulating neuronal activities. It has the advantage of high spatial resolution and penetration depth. Neuronal firing rhythms carry and transmit nerve information in neural systems. In this study, we investigated the phase-locking characteristics of neuronal firing rhythms with TMAS based on the Hodgkin-Huxley neuron model. The simulation results indicate that the modulation frequency of ultrasound can affect the phase-locking behaviors. The results of this study may help us to explain the potential firing mechanism of TMAS."
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Hodgkin-Huxley neuron
Model Concept(s): Action Potentials; Extracellular Fields; Locking, mixed mode; Magnetic stimulation; Methods
Simulation Environment: MATLAB (web link to model)
Implementer(s): Yuan, Yi [yuanyi513 at ysu.edu.cn]; Pang, Na; Chen, Yudong ; Wang, Yi
References:
Wang Y, Chen Y, Li X, Yuan Y, Pang N. (2017). A Phase-Locking Analysis of Neuronal Firing Rhythms with Transcranial Magneto-Acoustical Stimulation Based on the Hodgkin-Huxley Neuron Model Frontiers in Computational Neuroscience. 11