Role of afferent-hair cell connectivity in determining spike train regularity (Holmes et al 2017)


"Vestibular bouton afferent terminals in turtle utricle can be categorized into four types depending on their location and terminal arbor structure: lateral extrastriolar (LES), striolar, juxtastriolar, and medial extrastriolar (MES). The terminal arbors of these afferents differ in surface area, total length, collecting area, number of boutons, number of bouton contacts per hair cell, and axon diameter (Huwe JA, Logan CJ, Williams B, Rowe MH, Peterson EH. J Neurophysiol 113: 2420 –2433, 2015). To understand how differences in terminal morphology and the resulting hair cell inputs might affect afferent response properties, we modeled representative afferents from each region, using reconstructed bouton afferents. ..."

Model Type: Neuron or other electrically excitable cell; Axon

Region(s) or Organism(s): Turtle vestibular system

Cell Type(s): Vestibular neuron; Turtle vestibular neuron

Currents: I A; I h; I K; I K,Ca; I L high threshold; I M; I Na,t; I_KD

Model Concept(s): Action Potentials; Activity Patterns

Simulation Environment: NEURON

Implementer(s): Holmes, William [holmes at ohio.edu]

References:

Holmes WR, Huwe JA, Williams B, Rowe MH, Peterson EH. (2017). Models of utricular bouton afferents: role of afferent-hair cell connectivity in determining spike train regularity. Journal of neurophysiology. 117 [PubMed]


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