"... In this study, we aim to quantify the effects of stimulation frequency and fiber diameter on AP (Action Potential) interactions involving collisions and loss of excitability. We constructed a mechanistic model of a myelinated nerve fiber receiving two inputs: the underlying physiological activity at the terminal end of the fiber, and an external stimulus applied to the middle of the fiber. We define conduction reliability as the percentage of physiological APs that make it to the somatic end of the nerve fiber. At low input frequencies, conduction reliability is greater than 95% and decreases with increasing frequency due to an increase in AP interactions. Conduction reliability is less sensitive to fiber diameter and only decreases slightly with increasing fiber diameter. Finally, both the number and type of AP interactions significantly vary with both input frequencies and fiber diameter. ..."
Model Type: Axon
Cell Type(s): Myelinated neuron
Model Concept(s): Action Potentials; Axonal Action Potentials; Action Potential Initiation; Reliability
Simulation Environment: MATLAB (web link to model); NEURON (web link to model)
Sadashivaiah V, Sacré P, Guan Y, Anderson WS, Sarma SV. (2018). Modeling the interactions between stimulation and physiologically induced APs in a mammalian nerve fiber: dependence on frequency and fiber diameter Journal of Computational Neuroscience