"Neurons utilize bursts of action potentials as an efficient and reliable way to encode information. It is likely that the intrinsic membrane properties of neurons involved in burst generation may also participate in preserving its temporal features. Here we examined the contribution of the persistent and resurgent components of voltage-gated Na+ currents in modulating the burst discharge in sensory neurons. Using mathematical modeling, theory and dynamic-clamp electrophysiology, we show that, distinct from the persistent Na+ component which is important for membrane resonance and burst generation, the resurgent Na+ can help stabilize burst timing features including the duration and intervals. ..."
Model Type: Neuron or other electrically excitable cell
Model Concept(s): Bursting; Action Potentials
Simulation Environment: MATLAB
Implementer(s): Venugopal, Sharmila [vsharmila at g.ucla.edu]
References:
Venugopal S et al. (2019). Resurgent Na+ Current Offers Noise Modulation in Bursting Neurons. PLoS computational biology. 15 [PubMed]