This model is a supplementary material for Schreglmann, Sebastian R., et al. "Non-invasive suppression of essential tremor via phase-locked disruption of its temporal coherence" Nature Communications (2021). The model demonstrates that phase-locked transcranial alternating current stimulation (tACS) is able to disrupt the tremor-related oscillations in the cerebellum, and its efficacy is highly dependent on the relative phase between the stimulation and tremor.
Model Type: Neuron or other electrically excitable cell; Realistic Network
Region(s) or Organism(s): Cerebellum
Cell Type(s): Cerebellum Purkinje GABA cell; Cerebellum deep nucleus neuron; Inferior olive neuron
Simulation Environment: NEURON
References:
Schreglmann SR et al. (2021). Non-invasive suppression of essential tremor via phase-locked disruption of its temporal coherence Nature communications. 12 [PubMed]