This paper presents a full spiking, biophysically detailed multi-compartment model of a human cortical layer 5 (L5) pyramidal cell, where model development was primarily based on morphological and electrophysiological data from the same neuron. Focus was placed on capturing distinctly human dynamics of the h-channel and led to the articulation of a novel model of this channel's dynamics in humans. This led to an explanation for the surprising lack of subthreshold resonance seen in these cells in the human as opposed to rodent setting.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Neocortex
Cell Type(s): Neocortex layer 5 pyramidal cell; Hodgkin-Huxley neuron
Currents: I h; I M; I Na,p; I Na,t; I K; I Calcium
Model Concept(s): Active Dendrites; Detailed Neuronal Models
Simulation Environment: NEURON
Implementer(s): Rich, Scott [sbrich at umich.edu]
References:
Rich S, Moradi Chameh H, Sekulic V, Valiante TA, Skinner FK. (2021). Modeling Reveals Human-Rodent Differences in H-Current Kinetics Influencing Resonance in Cortical Layer 5 Neurons. Cerebral cortex (New York, N.Y. : 1991). 31 [PubMed]