"Biophysical computer modeling of a thalamic neuron demonstrated that an increase in rebound spiking can also be accounted for by a decrease in the M-type potassium current. Modeling also showed that an increase in sag with hyperpolarizing steps found after 6-OHDA treatment could in part but not fully be accounted for by the decrease in M-type current. These findings support the hypothesis that homeostatic changes in BGMT neural properties following 6-OHDA treatment likely influence the signal processing taking place in the BG thalamocortical network in Parkinson's disease."
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Thalamus
Currents: I A; I h; I L high threshold; I T low threshold; I K,Ca; I Sodium; I Potassium; I Na,p; I K
Model Concept(s): Pathophysiology
Simulation Environment: NEURON; Python
References:
Bichler EK, Cavarretta F, Jaeger D. (2021). Changes in Excitability Properties of Ventromedial Motor Thalamic Neurons in 6-OHDA Lesioned Mice. eNeuro 8 [PubMed]