Long-lasting effects on synaptic efficacies are associated with the sustained increase in concentration of specific proteins like PKM?. Assuming that the long-term maintenance of synaptic plasticity is accomplished by a molecular switch we perform simulations using the reaction-diffusion package in NEURON and analytical calculations to determine the limits of synapse specificity during maintenance.
Model Concept(s): Reaction-diffusion; Synaptic Plasticity; Learning
Simulation Environment: NEURON; MATLAB
Implementer(s): Newton, Adam J H [adam.newton at yale.edu]
References:
Huertas MA, Newton AJH, McDougal RA, Sacktor TC, Shouval HZ. (2022). Conditions for synaptic specificity during the maintenance phase of synaptic plasticity eNeuro.