Dynamics of ERK signaling pathways during L-LTP induction(Miningou et al 2021)

Biochemical model of five signaling pathways (3 activated by cAMP and 2 activated by calcium) leading to ERK activation during L-LTP induction. Simulations show that calcium and cAMP work synergistically to activate ERK and that stimuli given with large inter-trial intervals activate more ERK than shorter intervals. Epac and RasGRF pathways contribute to early dynamics and PKA and CaMKII contribute to late dynamics of ERK activation.

Model Type: Molecular Network

Region(s) or Organism(s): Hippocampus

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Model Concept(s): Long-term Synaptic Plasticity; Stochastic simulation; Reaction-diffusion

Simulation Environment: NeuroRD

Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Jedrzejewska-Szmek, Joanna


Miningou Zobon NT, Jędrzejewska-Szmek J, Blackwell KT. (2021). Temporal pattern and synergy influence activity of ERK signaling pathways during L-LTP induction eLife 10 [PubMed]