Biochemical model of five signaling pathways (3 activated by cAMP and 2 activated by calcium) leading to ERK activation during L-LTP induction. Simulations show that calcium and cAMP work synergistically to activate ERK and that stimuli given with large inter-trial intervals activate more ERK than shorter intervals. Epac and RasGRF pathways contribute to early dynamics and PKA and CaMKII contribute to late dynamics of ERK activation.
Model Type: Molecular Network
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Model Concept(s): Long-term Synaptic Plasticity; Stochastic simulation; Reaction-diffusion
Simulation Environment: NeuroRD
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Jedrzejewska-Szmek, Joanna
References:
Miningou Zobon NT, Jędrzejewska-Szmek J, Blackwell KT. (2021). Temporal pattern and synergy influence activity of ERK signaling pathways during L-LTP induction eLife 10 [PubMed]