Electrical synaptic transmission and voltage-gated ionic currents are often studied independently from one another. This model allows to study the interactions between the hyperpolarization-activated inward ionic current and a rectifying electrical synapse. Two single compartment nonspiking neurons are coupled through a rectifying electrical synapse. Current pulses are applied into the presynaptic neuron. The amplitude of the electrical postsynaptic potentials is measured. Ih can be added to either the pre- or postsynaptic neuron, or both. The cells represent the the MCN1 and LG neurons in the crab stomatogastric ganglion.
Model Type: Synapse; Neuron or other electrically excitable cell
Region(s) or Organism(s): Stomatogastric ganglion
Cell Type(s): Stomatogastric Ganglion (STG) Modulatory commissural neuron 1 (MCN1); Stomatogastric Ganglion (STG) Lateral Gastric (LG) cell; Hodgkin-Huxley neuron
Currents: I h
Model Concept(s): Invertebrate
Simulation Environment: Mathematica
Implementer(s): Harris, Allison L; Stein, Wolfgang [wstein@ilstu.edu]
References:
Stein W et al. (2022). The dynamic range of voltage-dependent gap junction signaling is maintained by Ih-induced membrane potential depolarization Journal of neurophysiology. 127 [PubMed]